I'm replacing a cracked throttle body intake boot on an 85 22r-e and I'm wondering if I should put some gasket sealer or something on the inside of the new boot or if I'm good to just clamp it on.

 

No sealer. You want to be able to remove it without damaging it. A very light smear of grease might be appropriate.

 

I, personally, use Vaseline. It helps the rubber last longer, and helps it seal better, as well. Not to mention making it easier to slide on/off. Anywhere I have rubber on metal, I use Vaseline. O-rings, vacuum lines, water hoses, you name it. Even my door seals, to keep them from freezing to the metal frame in the winter. It actually soaks into the rubber, swelling it slightly, and preserving it's flexibility, and so on.
I even used it on the o-ring in the throttle body that controls the idle speed. Haven't a bit of trouble out of it, and it's original.

I got the Vaseline trick from a guy that replaced my house's water system's filters once. He told me to put Vaseline on the o-rings. He'd been doing home water systems for years. The water in Yuma is terrible, so he did a lot of systems!.
I did, and never had one go bad, that wasn't my fault for pinching it or something. Works great on rubber hoses, o-rings, etc in vehicles, too. Not rubber in contact with gasoline, however. Other than that...

Good luck!
Pat☺